Publications

  1. Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Gao Q, Flint TR, Young L, Connell CM, Lukey MJ, Goncalves MD, White EP, Venkitaraman AR, Janowitz T. (June 2023) Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. Cell Metab. 2023 Jun 7:S1550-4131(23)00185-7. doi: 10.1016/j.cmet.2023.05.008. Online ahead of print.PMID: 37311455

  2. Liu Y, Dantas E, Ferrer M, Liu Y, Comjean A, Davidson EE, Hu Y, Goncalves MD, Janowitz T, Perrimon N. (May 2023) Tumor Cytokine-Induced Hepatic Gluconeogenesis Contributes to Cancer Cachexia: Insights from Full Body Single Nuclei Sequencing. bioRxiv. 2023 May 18:2023.05.15.540823. doi: 10.1101/2023.05.15.540823. Preprint.PMID: 37292804 Free PMC article.

  3. Ferrer M, Anthony TG, Ayres JS, Biffi G, Brown JC, Caan BJ, Cespedes Feliciano EM, Coll AP, Dunne RF, Goncalves MD, Grethlein J, Heymsfield SB, Hui S, Jamal-Hanjani M, Lam JM, Lewis DY, McCandlish D, Mustian KM, O'Rahilly S, Perrimon N, White EP, Janowitz T. (April 2023) Cachexia: A systemic consequence of progressive, unresolved disease. Cell. 27;186(9):1824-1845. doi: 10.1016/j.cell.2023.03.028.PMID: 37116469 Review.

  4. Mou H, Eskiocak O, Özler KA, Gorman M, Yue J, Jin Y, Wang Z, Gao Y, Janowitz T, Meyer HV, Yu T, Wilkinson JE, Kucukural A, Ozata DM, Beyaz S. (April 2023) CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer. J Pathol. 2023 Apr;259(4):415-427. doi: 10.1002/path.6054. Epub 2023 Feb 8.PMID: 36641763

  5. Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Flint TR, Connell CM, Lukey M, White EP, Coll AP, Venkitaraman AR, Janowitz T. (Feb 2023) Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. bioRxiv. bioRxiv. 2023 Feb 18:2023.02.17.528937. doi: 10.1101/2023.02.17.528937. Preprint.PMID: 36824830 Free PMC article.

  6. Sun Q, van de Lisdonk D, Ferrer M, Gegenhuber B, Wu M, Tollkuhn J, Janowitz T, Li B. (Jan 2023) Area postrema neurons mediate interleukin-6 function in cancer-associated cachexia. bioRxiv. 2023 Jan 14:2023.01.12.523716. doi: 10.1101/2023.01.12.523716. Preprint.PMID: 36711916 Free PMC article.

  7. Furlan A, Corona A, Boyle S, Sharma R, Rubino R, Habel J, Gablenz EC, Giovanniello J, Beyaz S, Janowitz T, Shea SD, Li B.(Nov 2022) Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis. Nat Neurosci. 2022 Nov;25(11):1470-1480. doi: 10.1038/s41593-022-01178-3. Epub 2022 Oct 20.PMID: 36266470 Free PMC article.

  8. Kleeman SO, Cordioli M, Timmers PRHJ, Khan A, Tober-Lau P, Kurth F, Demichev V, Meyer HV, Wilson JF, Ralser M, Kiryluk K, Ganna A, Baillie K, Janowitz T.(Oct 2022) Cystatin C is associated with adverse COVID-19 outcomes in diverse populations. iScience. 2022 Oct 21;25(10):105040. doi: 10.1016/j.isci.2022.105040. Epub 2022 Aug 31.PMID: 36062073 Free PMC article.

  9. Song D, Adrover JM, Felice C, Christensen LN, He XY, Merrill JR, Wilkinson JE, Janowitz T, Lyons SK, Egeblad M, Tonks NK. (July 2022) PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils. JCI Insight. 2022 Jul 22;7(14):e158199. doi: 10.1172/jci.insight.158199.PMID: 35866483 Free PMC article.

  10. Ferrer M, Janowitz T.(July 2022) Training the host organism to enhance anti-cancer immunity. Cancer Cell. 2022 Jul 11;40(7):703-705. doi: 10.1016/j.ccell.2022.06.003. Epub 2022 Jun 23.PMID: 35750051

  11. Sam O. Kleeman, Breanna Demestichas, Nicholas Mourikis, Dominik Loiero, Miriam Ferrer, Sean Bankier, Yosef J.R.A. Riazat-Kesh, Hassal Lee, Dimitrios Chantzichristos, Claire Regan, Jonathan Preall, Sarthak Sinha, Nicole Rosin, Bryan Yipp, Luiz G.N. de Almeida, Jeff Biernaskie, Antoine Dufour, Pinkus Tober-Lau, Arno Ruusalepp, Johan L. M. Bjorkegren, Markus Ralser, Florian Kurth, Vadim Demechev, Todd Heywood, Qing Gao, Gudmundur Johannsson, Viktor H. Koelzer, Brian R. Walker, Hannah V. Meyer, Tobias Janowitz (June 2022) Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy

  12. Brennan C, Nadella S, Zhao X, Dima R, Jordan-Martin N, Demestichas B, Kleeman S, Ferrer M, von Gablenz E, Mourikis N, Rubin M, Adnani H, Lee H, Ha T, Prum S, Schleicher C, Fox S, Ryan M, Pili C, Goldberg G, Crawford J, Goodwin S, Zhang X, Preall J, Costa A, Conigliaro J, Masci J, Yang J, Tuveson D, Tracey K, Janowitz T (Jan 2022) Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial. Gut. 2022 May;71(5):879-888. doi: 10.1136/gutjnl-2022-326952. Epub 2022 Feb 10.PMID: 35144974 Free PMC article. Clinical Trial.

  13. Wang Z, Moresco P, Yan R, Li J, Gao Y, Biasci D, Yao M, Pearson J, Hechtman JF, Janowitz T, Zaidi RM, Weiss MJ, Fearon DT. (Jan 2022) Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack. Proc Natl Acad Sci U S A; 119(4):e2119463119. doi: 10.1073/pnas.2119463119.

  14. Furlan, A., Corona, A., Boyle, S., Sharma, R., Rubino, R., Habel, J., Gablenz, E., Giovanniello, J., Beyaz, S., Janowitz, T., Shea, S., Stephen, D., Li, B. (August 2021) Neurotensin neurons in the central extended amygdala control energy balance. BioRxiv. https://doi.org/10.1101/2021.08.03.454970

  15. Kolamunnage-Dona, R., Berhane, S., Potts, H., Williams, E. H., Tanner, J., Janowitz, T., Hoare, M., Johnson, P. (May 2021) Sorafenib is associated with a reduced rate of tumour growth and liver function deterioration in HCV-induced hepatocellular carcinoma. Journal of Hepatology. ISSN 0168-8278

  16. Yang, W.-H., Qiu, Y., Stamatatos, O., Janowitz, T., Lukey, M. J. (May 2021) Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy. Trends in Cancer. ISSN 2405-8033

  17. Janowitz, T., Kleeman, S., Vonderheide, R. H. (April 2021) Reconsidering Dexamethasone for Antiemesis when Combining Chemotherapy and Immunotherapy. The Oncologist, 26 (4). pp. 269-273. ISSN 1083-7159

  18. Fearon, D. T., Janowitz, T. (March 2021) AMD3100/Plerixafor overcomes immune inhibition by the CXCL12-KRT19 coating on pancreatic and colorectal cancer cells. British Journal of Cancer. ISSN 0007-0920

  19. Williams, E. H., Flint, T. R., Connell, C. M., Giglio, D., Lee, H., Ha, T., Gablenz, E., Bird, N. J., Weaver, J. M. J., Potts, H., Whitley, C. T., Bookman, M. A., Lynch, A. G., Meyer, H. V., Tavaré, S., Janowitz, T. (March 2021) CamGFR v2: A New Model for Estimating the Glomerular Filtration Rate from Standardized or Non-standardized Creatinine in Patients with Cancer. Clinical Cancer Research, 27 (5). pp. 1381-1390. ISSN 1078-0432

  20. Munir, H., Jones, J. O., Janowitz, T., Hoffmann, M., Euler, M., Martins, C. P., Welsh, S. J., Shields, J. D. (January 2021) Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth. Nature Communications, 12 (1). p. 683. ISSN 2041-1723

  21. Biasci, D., Smoragiewicz, M., Connell, C. M., Wang, Z., Gao, Y., Thaventhiran, J. E. D., Basu, B., Magiera, L., Johnson, T. I., Bax, L., Gopinathan, A., Isherwood, C., Gallagher, F. A., Pawula, M., Hudecova, I., Gale, D., Rosenfeld, N., Barmpounakis, P., Popa, E. C., Brais, R., Godfrey, E., Mir, F., Richards, F. M., Fearon, D. T., Janowitz, T., Jodrell, D. I. (November 2020) CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response. Proc Natl Acad Sci U S A, 117 (46). pp. 28960-28970. ISSN 0027-8424 (Print)0027-8424

  22. Weber, A. G., Chau, A. S., Egeblad, M., Barnes, B. J., Janowitz, T. (September 2020) Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series. Mol Med, 26 (1). p. 91. ISSN 1076-1551 (Print)1076-1551

  23. Janowitz, T., Gablenz, E., Pattinson, D., Wang, T. C., Conigliaro, J., Tracey, K., Tuveson, D. (June 2020) Famotidine Use and Quantitative Symptom Tracking for COVID-19 in Non-Hospitalised Patients: A Case Series. Gut, 69 (9). pp. 1592-1597. ISSN 1468-3288

  24. Janowitz, T., Tuveson, D. A. (May 2020) The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research. Cancer Discov, 10 (7). pp. 913-915. ISSN 2159-8274

  25. Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., Hynes, R. O., Jain, R. K., Janowitz, T., Jorgensen, C., Kimmelman, A. C., Kolonin, M. G., Maki, R. G., Powers, R. S., Pure, E., Ramirez, D. C., Scherz-Shouval, R., Sherman, M. H., Stewart, S., Tlsty, T. D., Tuveson, D. A., Watt, F. M., Weaver, V., Weeraratna, A. T., Werb, Z. (March 2020) A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer, 20 (3). pp. 174-186. ISSN 1474-175x

  26. Connell, C. M., Brais, Rebecca, Whitaker, Hayley, Upponi, Sara, Beh, Ian, Risdall, Jane, Corrie, Pippa, Janowitz, Tobias, Jodrell, Duncan I .(January 2020) Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report. BMC Cancer, 20 (1). p. 38. ISSN 1471-2407

  27. Williams, Edward H, Connell, Claire M, Weaver, James MJ, Beh, Ian, Potts, Harry, Whitley, Cameron T, Bird, Nicholas, Al-Sayed, Tamer, Monaghan, Phillip J, Fehr, Martin, Cathomas, Richard, Bertelli, Gianfilippo, Quinton, Amy, Lewis, Paul, Shamash, Jonathan, Wilson, Peter, Dooley, Michael, Poole, Susan, Mark, Patrick B, Bookman, Michael A, Earl, Helena, Jodrell, Duncan, Tavaré, Simon, Lynch, Andy G, Janowitz, Tobias (December 2019) Multicenter Validation of the CamGFR Model for Estimated Glomerular Filtration Rate. JNCI Cancer Spectrum, 3 (4). pkz068. ISSN 2515-5091

  28. Luo, Y., Yang, Y., Liu, M., Wang, D., Wang, F., Bi, Y., Ji, J., Li, S., Liu, Y., Chen, R., Huang, H., Wang, X., Swidnicka-Siergiejko, A. K., Janowitz, T., Beyaz, S., Wang, G., Xu, S., Bialkowska, A. B., Luo, C. K., Pin, C. L., Liang, G., Lu, X., Wu, M., Shroyer, K. R., Wolff, R. A., Plunkett, W., Ji, B., Li, Z., Li, E., Li, X., Yang, V. W., Logsdon, C. D., Abbruzzese, J. L., Lu, W. (July 2019) Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet. Gastroenterology, 157 (5). ISSN 0016-5085

  29. Janowitz, T. (July 2018) Cancer: The Tumor-Driven Disease of the Host. Cell Metab, 28 (1). pp. 5-6. ISSN 1550-4131

  30. Sng, C. C. T., O'Byrne, S., Prigozhin, D. M., Bauer, M. R., Harvey, J. C., Ruhle, M., Challis, B. G., Lear, S., Roberts, L. D., Workman, S., Janowitz, T., Magiera, L., Doffinger, R., Buckland, M. S., Jodrell, D. J., Semple, R. K., Wilson, T. J., Modis, Y., Thaventhiran, J. E. D. (July 2018) A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway. J Allergy Clin Immunol, 142 (1). 311-314.e6. ISSN 0091-6749

  31. Casey, R. T., Giger, O., Seetho, I., Marker, A., Pitfield, D., Boyle, L. H., Gurnell, M., Shaw, A., Tischowitz, M., Maher, E. R., Chatterjee, V. K., Janowitz, T., Mells, G., Corrie, P., Challis, B. G. (June 2018) Rapid disease progression in a patient with mismatch repair-deficient and cortisol secreting adrenocortical carcinoma treated with pembrolizumab. Semin Oncol. ISSN 0093-7754

  32. Flint, T. R., Jones, J. O., Ferrer, M., Colucci, F., Janowitz, T. (March 2018) A comparative analysis of immune privilege in pregnancy and cancer in the context of checkpoint blockade immunotherapy. Semin Oncol. ISSN 0093-7754

  33. Connell, C. M., Raby, S. E. M., Beh, I., Flint, T. R., Williams, E. H., Fearon, D. T., Jodrell, D. I., Janowitz, T. (January 2018) Cancer Immunotherapy Trials Underutilize Immune Response Monitoring. Oncologist, 23 (1). pp. 116-117. ISSN 1083-7159

  34. Janowitz, T., Williams, E. H., Marshall, A., Ainsworth, N., Thomas, P. B., Sammut, S. J., Shepherd, S., White, J., Mark, P. B., Lynch, A. G., Jodrell, D. I., Tavare, S., Earl, H. (August 2017) New Model for Estimating Glomerular Filtration Rate in Patients With Cancer. J Clin Oncol, 35 (24). pp. 2798-2805. ISSN 0732-183x

  35. Connell, C. M., Raby, S., Beh, I., Flint, T., Williams, E., Fearon, D. T., Jodrell, D. I., Janowitz, T. (July 2017) Cancer immunotherapy trial registrations increase exponentially but chronic immunosuppressive glucocorticoid therapy may compromise outcomes. Ann Oncol, 28 (7). pp. 1678-1679. ISSN 0923-7534

  36. Flint, Thomas R., Fearon, Douglas T., Janowitz, Tobias (May 2017) Connecting the Metabolic and Immune Responses to Cancer. Trends in Molecular Medicine, 23 (5). pp. 451-464. ISSN 1471-4914

  37. Fessas, P., Lee, H., Ikemizu, S., Janowitz, T. (April 2017) A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab. Semin Oncol, 44 (2). pp. 136-140. ISSN 0093-7754

  38. Flint, T. R., Janowitz, T., Connell, C. M., Roberts, E. W., Denton, A. E., Coll, A. P., Jodrell, D. I., Fearon, D. T. (November 2016) Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity. Cell Metab. 2016 Nov 8;24(5):672-684. doi: 10.1016/j.cmet.2016.10.010.PMID: 27829137 Free PMC article.

  39. Janowitz, T., Thuss-Patience, P., Marshall, A., Kang, J. H., Connell, C., Cook, N., Dunn, J., Park, S. H., Ford, H. (February 2016) Chemotherapy vs supportive care alone for relapsed gastric, gastroesophageal junction, and oesophageal adenocarcinoma: a meta-analysis of patient-level data. Br J Cancer, 114 (4). pp. 381-7. ISSN 0007-0920

  40. Janowitz, T., Welsh, S., Warren, A. Y., Robson, J., Thomas, B., Shaw, A., Ainsworth, N. L., Neal, D. E., Mazhar, D. (October 2015) Prostatic relapse of an undifferentiated teratoma 24 years after orchidectomy. BMC Res Notes, 8. p. 524. ISSN 1756-0500

  41. Gill, A. B., Anandappa, G., Patterson, A. J., Priest, A. N., Graves, M. J., Janowitz, T., Jodrell, D. I., Eisen, T., Lomas, D. J. (February 2015) The use of error-category mapping in pharmacokinetic model analysis of dynamic contrast-enhanced MRI data. Magn Reson Imaging, 33 (2). pp. 246-51. ISSN 0730-725x

  42. Lu, L., Yan, H., Shyam-Sundar, V., Janowitz, T. (September 2014) Cross-sectional and longitudinal analysis of cancer vaccination trials registered on the US Clinical Trials Database demonstrates paucity of immunological trial endpoints and decline in registration since 2008. Drug Des Devel Ther, 8. pp. 1539-53. ISSN 1177-8881

  43. Ellul, M., Janowitz, T., Burnet, N.(May 2014) Panhypopituitarism secondary to a solitary hypothalamic metastasis. BMJ Case Rep, 2014. ISSN 1757-790x

  44. Li, L. M., Menon, D. K., Janowitz, T. (January 2014) Cross-sectional analysis of data from the U.S. clinical trials database reveals poor translational clinical trial effort for traumatic brain injury, compared with stroke. PLoS One, 9 (1). e84336. ISSN 1932-6203

  45. Ford, H. E., Marshall, A., Bridgewater, J. A., Janowitz, T., Coxon, F. Y., Wadsley, J., Mansoor, W., Fyfe, D., Madhusudan, S., Middleton, G. W., Swinson, D., Falk, S., Chau, I., Cunningham, D., Kareclas, P., Cook, N., Blazeby, J. M., Dunn, J. A. (January 2014) Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial. Lancet Oncol, 15 (1). pp. 78-86. ISSN 1470-2045

  46. Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., Teichmann, S. A., Janowitz, T., Jodrell, D. I., Tuveson, D. A., Fearon, D. T. (December 2013) Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 110 (50). pp. 20212-20217. ISSN 00278424 (ISSN)

  47. Janowitz, T., Welsh, S. J., Zaki, K., Mulders, P., Eisen, T. (August 2013) Adjuvant therapy in renal cell carcinoma-past, present, and future. Semin Oncol, 40 (4). pp. 482-91. ISSN 0093-7754

  48. Ubhi, B. K., Cheng, K. K., Dong, J., Janowitz, T., Jodrell, D., Tal-Singer, R., MacNee, W., Lomas, D. A., Riley, J. H., Griffin, J. L., Connor, S. C. (October 2012) Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD. Mol Biosyst, 8 (12). pp. 3125-33. ISSN 1742-2051

  49. Janowitz, T. (January 2011) Biopharmaceuticals and monoclonal antibodies in oncology trials--a cross-sectional analysis. Protein Eng Des Sel, 24 (1-2). pp. 105-11. ISSN 1741-0126

  50. Janowitz, T., Menon, D. K. (April 2010) Exploring new routes for neuroprotective drug development in traumatic brain injury. Sci Transl Med, 2 (27). 27rv1. ISSN 1946-6234

  51. Oliynyk, Z., Briseno-Roa, L., Janowitz, T., Sondergeld, P., Fersht, A. R. (April 2004) Designing a metal-binding site in the scaffold of Escherichia coli KDO8PS. Protein Eng Des Sel, 17 (4). pp. 383-90. ISSN 1741-0126 (Print)1741-0126

  52. Koulen, P., Janowitz, T., Johenning, F. W., Ehrlich, B. E. (October 2001) Characterization of the calcium-release channel/ryanodine receptor from zebrafish skeletal muscle. J Membr Biol, 183 (3). pp. 155-63. ISSN 0022-2631 (Print)0022-2631

  53. Koulen, P., Janowitz, T., Johnston, L. D., Ehrlich, B. E. (September 2000) Conservation of localization patterns of IP(3) receptor type 1 in cerebellar Purkinje cells across vertebrate species. J Neurosci Res, 61 (5). pp. 493-9. ISSN 0360-4012 (Print)0360-4012